Objective: Currently there is no specific detection method and index in the diagnosis of preschool children's asthma. To analyze the difference distribution of FCER2 T2206C and LTC4S A444C in Kazak

Han and Uygur preschool children with suspected asthma of Xinjiang. To provide the early diagnosis basis of asthma for preschool children who are susceptible to asthma of different nationalities in Xinjiang. Methods: The polymorphism of FCER2 T2206C and LTC4S A444C genes in 245 preschool children with asthma in Xinjiang (including 48 Kazak

68 Uygur and 129 Han) were detected by fluorescence staining in situ hybridization

and the differences of genotype frequency and allele frequency among different nationalities and different regions were analyzed. Results: Among 245 preschool children with suspected asthma in Xinjiang

there were significant differences in LTC4S A-444C genotype frequency and allele frequency between Han children and Uygur and Kazak children (P<0.05); There was no significant difference in FCER2 T2206C genotype and allele frequency among the three nationalities (P>0.05). Conclusion: There was statistical difference on genetic polymorphism of LTC4S A-444C between three nationalities in preschool children suspected with asthma of Xinjiang. Through this study

we can provide the basis for screening or early diagnosis of suspected asthma in preschool children of different nationalities in Xinjiang

and early intervention or treatment of asthma in children. So as to further explore the molecular diagnosis method

disease prediction and prevention and treatment of children's bronchial asthma.